Reminder: one of the major projects initiated by Fondation FondaMental Suisse consists in building a shared biobank and a common clinical database: this will make it possible to identify biomarkers (genetic, epigenetic, endocrine, inflammatory, cognitive, etc.) associated with bipolar disorders, then with OCD, hyperactivity, borderline personality disorders, depression

Thanks to the foundation’s support, the Department of Psychiatry (HUG/UNIGE) has already set up a biobank composed of biological samples, as well as clinical data from patients suffering from bipolar disorder.

The biobank also collects magnetic resonance imaging (MRI) data, as well as electrophysiological data obtained by electroencephalogram (EEG).
The biobank is composed of biological data from nearly 200 patients and covers a spectrum of conditions often associated with bipolar disorder, such as attention deficit/hyperactivity disorder or borderline personality disorder. In addition, this biobank has data from nearly 100 control subjects that can be compared with data from patients with bipolar disorder and related disorders.

Thanks to data sharing with the French biobank of FondaMental France bipolar disorders Expert Centres, Franco-Swiss collaborations have made it possible to carry out joint scientific work that has resulted in the joint publications below.

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Clinical publications:

Impulsivity and its association with childhood trauma experiences across bipolar disorder, attention deficit hyperactivity disorder and borderline personality disorder.

Similarities between emotional dysregulation in adults suffering from ADHD and bipolar patients.

The DNA of the Franco-Swiss biobanks thus formed made it possible to join the international consortium ConLiGen, with the following publications:

Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study.

Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder.

Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.

Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.